Skin ageing is a biochemical process that principally takes place in the lower epidermis and in the dermis. It can be intrinsic or chronological aging and extrinsic or environmental aging.

Various environmental factors ,UV-irradiation, air pollution, smoking, poor diet, alcohol, dry weather and stress are responsible for extrinsic aging. Among them UV-irradiation is the most fundamental one, as it can damage skin to such an extent, that makes it seem prematurely aged (photoaging). Photoaging is the main cause of wrinkles.

Ageing is the consequence of lower production and increased breakdown of the proteins, collagen and elastin, that impart firmness and elasticity to the skin. Protein glycation, a non-enzymatic reaction of proteins( collagen and elastin), results in cross-linked proteins called AGE (Advanced Glycation End-products), responsible for deterioration of the existing collagen and elastin .UV radiations accelerates normal ageing by promoting glycation through oxidative stress.

Major contributing mechanism in ageing is the Reactive oxygen species(ROS), initiating and activating a complex cascade of biochemical reactions in human skin, thus interfering with the synthesis of dermal collagen.